The result is a horrible mess of a movie, without shape, trajectory or purpose - a one joke movie, if it had one joke. The two characters wander witlessly past the bizarre backdrops of Las Vegas (some real, some hallucinated, all interchangeable) while zonked out of their minds. Humor depends on attitude. Beyond a certain point, you don't have an attitude, you simply inhabit a state. I've heard a lot of funny jokes about drunks and druggies, but these guys are stoned beyond comprehension, to the point where most of their dialog could be paraphrased as "eh?"... As for Depp, what was he thinking he made this movie? He was once in trouble for trashing a New York hotel room, just like the heroes of Fear and Loathing in Las Vegas. What was that? Research? After River Phoenix died of an overdose outside Depp's club, you wouldn't think Depp would see much humor in this story - but then, of course, there *isn't* much humor in this story.