Four hundred years ago, ships set sail from the west coast of Africa and in the process, began one of mankind's most inhumane practices: human bondage and slavery. For two centuries, human beings – full of hopes and fears, dreams and concerns, ambition and anguish – were transported onto ships like chattel, and the lives of many forever changed. The reverberations from this horrific series of acts – a transatlantic slave trade that touched the shores of a colony that came to be known as America, and later a democratic republic known as the United States of America – are unknown and worthy of exploration. Approximately 4,000,000 Africans and their descendants were enslaved in the United States and colonies that became the United States from 1619 to 1865.