In most theoretical embodiments of inflationary cosmology, the currently observed universe appears as a small part of a much larger multiverse. In this framework to hold throughout the universe need not hold through all space. They can be accidents of our local geography, so to speak. If that is so, then it is valid – indeed, necessary – to consider selection effects. It may be that some of the "fundamental constants”, in particular, cannot be determined by theoretical reasoning, even in principle, because they really are different elsewhere.