Simple rules can have complex consequences. This simple rule has such a wealth of implications that it is worth examining in detail. It is the far from self-evident guiding principle of reductionism and of most modern investigations into cosmic complexity. Reductionism will not be truly successful until physicists and cosmologists demonstrate that the large-scale phenomena of the world arise from fundamental physics alone. This lofty goal is still out of reach. There is uncertainty not only in how physics generates the structures of our world but also in what the truly fundamental rules of physics are.