An autopoietic machine is a machine organized (defined as a unity) as a network of processes of production (transformation and destruction) of components which:
(i) through their interactions and transformations continuously regenerate and realize the network of processes (relations) that produced them; and
(ii) constitute it (the machine) as a concrete unity in space in which they (the components) exist by specifying the topological domain of its realization as such a network. (Humberto Maturana)

An autopoietic machine is a machine organized (defined as a unity) as a network of processes of production (transformation and destruction) of components which: (i) through their interactions and transformations continuously regenerate and realize the network of processes (relations) that produced them; and (ii) constitute it (the machine) as a concrete unity in space in which they (the components) exist by specifying the topological domain of its realization as such a network.

Humberto Maturana

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concrete constitute destruction domain machine network production realization regenerate space specifying transformation unity relations

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