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Often it is not physical limitations... but rather it is human made laws, habits, and organizational rules, regulations, personal egos, and inertia, which dominate the evolution of the future.
Richard Hamming
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Mathematicians have tried in vain to this day to discover some order in the sequence of prime numbers, and we have reason to believe that it is a mystery into which the human mind will never penetrate.
Leonhard Euler
God does not die on the day when we cease to believe in a personal deity, but we die on the day when our lives cease to be illumined by the steady radiance, renewed daily, of a wonder, the source of which is beyond all reason.
Dag Hammarskjöld
Life is not an easy matter... You cannot live through it without falling into frustration and cynicism unless you have before you a great idea which raises you above personal misery, above weakness, above all kinds of perfidy and baseness.
Leon Trotsky
Mistakes are a part of being human. Appreciate your mistakes for what they are: precious life lessons that can only be learned the hard way. Unless it's a fatal mistake, which, at least, others can learn from.
Al Franken
The effort to understand the universe is one of the very few things which lifts human life a little above the level of farce and gives it some of the grace of tragedy.
Steven Weinberg