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Whenever a theory appears to you as the only possible one, take this as a sign that you have neither understood the theory nor the problem which it was intended to solve.
Karl Popper
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Writing a book is a horrible, exhausting struggle, like a long bout with some painful illness. One would never undertake such a thing if one were not driven on by some demon whom one can neither resist nor understand.
George Orwell
Here was a problem, that I, a ten year old, could understand and I knew from that moment that I would never let it go. I had to solve it.
Andrew Wiles
Discussion in class, which means letting twenty young blockheads and two cocky neurotics discuss something that neither their teacher nor they know.
Vladimir Nabokov
Man, being the servant and interpreter of nature, can do and understand so much and so much only as he has observed in fact or in thought of the course of nature beyond this he neither knows anything nor can do anything.
Francis Bacon
... vicissitudes of fortune, which spares neither man nor the proudest of his works, which buries empires and cities in a common grave.
Edward Gibbon